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Buy Nubain nalbuphine HCL Injection | Nubain nalbuphine HCL Injection for sale , narcotic use as a pain medication. Also, It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | nalbuphine hydrochloride injection | injection de nubain
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Nalbuphine is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series. Nalbuphine’s analgesic potency is essentially equivalent to that of morphine on a milligram basis. Therefore, The opioid antagonist activity of nalbuphine is one-fourth as potent as nalorphine and 10 times that of pentazocine. However, Nalbuphine by itself has potent opioid antagonist activity at doses equal to or lower than its analgesic dose. When administered following or concurrent with mu agonist opioid analgesics (e.g., morphine, oxymorphone, fentanyl), nalbuphine may partially reverse or block opioid-induced respiratory depression from the mu agonist analgesic. Also, Nalbuphine may precipitate withdrawal in patients dependent on opioid drugs. Use Nalbuphine with caution in patients who have been receiving mu opioid analgesics on a regular basis. injection de nubain
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The exact mechanism of action is unknown, but believed to interact with an opiate receptor site in the CNS (probably in or associated with the limbic system). However, The opiate antagonistic effect may result from competitive inhibition at the opiate receptor, but may also be a result of other mechanisms. Nalbuphine is thought primarily to be a kappa agonist. Therefore, It is also a partial mu antagonist analgesic, with some binding to the delta receptor and minimal agonist activity at the sigma receptor. Buy Nubain nalbuphine HCL Injection
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The mean absolute bioavailability was 81% and 83% for the 10 and 20 mg intramuscular doses, respectively, and 79% and 76% following 10 and 20 mg of subcutaneous nalbuphine.
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The plasma half-life of nalbuphine is 5 hours, and in clinical studies, the duration of analgesic activity has been reported to range from 3 to 6 hours.
Oral, acute LD50 is 1100 mg/kg in a dog. Symptoms of overdose include primarily sleepiness and mild dysphoria.
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